Synthesis of A Novel Mono-hydroxyl Chloro-corrole and Its Photocleavage of DNA
SHI Lei1, YANG Wen-cong1, ZENG Shu-ying1,MO Ting-ting1, WANG Hua-hua2, LIU Hai-yang2
1. Department of Chemistry, Guangdong University of Education, Guangzhou 510303, China; 2. School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China
Abstract：5-(Pentafluoro-phenyl)-dipyrromethane(1) was prepared by condensation reaction of pentafluorobenzaldehyde with pyrrole. A novel mono-hydroxyl corrole, 10-(3-chloro-4-hydroxylphenyl)-5,15-bis(pentafluorophenyl) corrole(2) with yield of 12.0%, was synthesized by condensation reaction of 1 with 3-chloro-4-hydroxylbenzaldehyde. The structure was characterized by UV-Vis， 1H NMR， 19F NMR, HR-ESI-MS and X-ray single crystal diffraction. Agarose gel electrophoresis showed that 2 could cleave 68% supercoiled DNA(form I) to give nicked-circular DNA(form II) under irradiation at 100 μmol·L-1.
史蕾， 杨文聪， 曾淑莹， 莫婷婷， 汪华华， 刘海洋. 新型单羟基氯代咔咯的合成及其光断裂DNA性质[J]. 合成化学, 2016, 24(4): 312-315.
SHI Lei, YANG Wen-cong, ZENG Shu-ying,MO Ting-ting, WANG Hua-hua, LIU Hai-yang. Synthesis of A Novel Mono-hydroxyl Chloro-corrole and Its Photocleavage of DNA. Chinese Journal of Synthetic Chemistry, 2016, 24(4): 312-315.
2016, Vol. 24 
