Abstract：Novel thienopyridine derivatives(3b~3e, 3g and 5a~5g) were synthesized by substitution reaction of tetrahydrothieno［3,2-c］pyridine or tetrahydrothieno［2,3-c］pyridine with substituted benzyl bromides, and salt forming reaction with ethereal hydrochloric acid. Novel thienopyridine derivatives(7d, 7e, 7g~7i) were synthesized by substitution reaction of tetrahydrothieno［3,2-c］pyridone with substituted benzyl bromides, and condensation with acetic anhydride, then salt forming with 2 mol·L-1 ethereal hydrochloric acid. The structures were characterized by 1H NMR and ESI-MS. The results in platelet aggregation inhibition tests in vivo showed that the compounds exhibited certain activities, 7d, 7h and 7i showed better activities than the positive control drug ticlopidine, and the inhibitory rate were 66.2%, 86.8% and 88.3%, respectively.
樊梦林， 姜希明， 刘颖， 刘登科， 王平保. 新型噻吩并四氢吡啶类化合物的合成及其抗血小板聚集活性[J]. 合成化学, 2016, 24(4): 297-301.
FAN Meng-lin, JIANG Xi-ming, LIU Ying, LIU Deng-ke, WANG Ping-bao. Synthesis and Anti-platelet Aggregation Activities of Novel Thienopyridine Derivatives. Chinese Journal of Synthetic Chemistry, 2016, 24(4): 297-301.
2016, Vol. 24 
