Abstract：Six novel choline derivatives of quaternary ammonium salts(3a~3f) were synthesized by reaction of N,N-dimethyl ethanolamine or N,N-diethyl ethanolamine with brominated alkanes of different carbon chain length under reflux condition. The structures were characterized by UV-Vis， 1H NMR and HR-MS. The antimalarial activities test showed that 3a~3f demonstrated different degrees of inhibiting effect on the growth of plasmodium falciparum 3D7 in vitro, and (1-hydroxy) diethyl -n-butyl ammonium bromide(3f) exhibited the strongest antimalarial activity with IC50 of (68.1±6.5) nmol·L-1, but lower than Artemisinin［IC50(5.7±1.54）nmol·L-1］.
2016, Vol. 24 
