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2023 Vol. 31, No. 1
Published: 2023-01-20
1
Synthesis and Anti-hypoxia Activities of Salidroside Derivatives
Synthesis and Anti-hypoxia Activities of Salidroside Derivatives[J]. journal1, 2023,31(1): 1-13')" href="#">
REN Xinjian, CUI Yaowen, CHEN Tingting, WEN Xiaoxue, PENG Tao, ZHANG Shouguo, WANG Lin
DOI: 10.15952/j.cnki.cjsc.1005-1511.22123
In order to find safe and effective anti-hypoxic molecules, a series of 25 novel salidroside derivatives R1~R10、 X1~X10 and J1~J5 were designed and synthesized using p-hydroxyphenylethanol and 1,2,3,4,6-
β
-D-glucosaccharide pentaacetate as starting materials. Their structures were confirmed by
1
H NMR,
13
C NMR and HR-MS(ESI), which have not been reported in the literature. The anti-hypoxia activities of the target compounds were evaluated by the hypoxia/reoxygenation model of H9C2 cardiomyocytes
in vitro
, then the cytotoxicities of
R7
,
X2
,
X8
and
J1
to human renal epithelial cells 293T, human lung epithelial cells BEAS-2B, rat cardiomyocytes H9C2 and human normal hepatocytes LO2 were evaluated. Finally, the
in vivo
anti-hypoxia activities of
R7
,
X8
and
J1
were further evaluated by atmospheric hypoxia mouse model. The results showed that
R7
,
X8
and
J1
exhibited significant anti-hypoxia activities
in vitro
and
in vivo
without significant cytotoxicity.
2023 Vol. 31 (1): 1-13 [
Abstract
] (
144
)
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(3061 KB) (
50
)
14
Preparation and Properties of Poly(butylenecarbonate-co-tricyclodecane dimethanol carbonate)
Preparation and Properties of Poly(butylenecarbonate-co-tricyclodecane dimethanol carbonate)[J]. journal1, 2023,31(1): 14-22')" href="#">
RAN Qiding, CHEN Xuejun, LI Jianguo, WANG Qingyin, WANG Ziqing, WANG Gongying
DOI: 10.15952/j.cnki.cjsc.1005-1511.22031
A series of Poly(butylene carbonate-co-tricyclodecane dimethanol carbonate)(PBTCx, x is the percentage of TCD in the total diol in the feed) were synthesized from 1,4-butanediol, 4,8-bis(hydroxymethyl)tricyclo[5.2.1.0(2,6)]decane and diphenyl carbonate by two-step method of melting transesterification and polycondensation. The microstructure and composition of PBTCs were characterized by 1H NMR and 13C NMR. The molecular weight, glass transition temperature(Tg) and thermal stability of PBTCs were researched by GPC, DSC, XRD and TG. The results showed that the Mw of PBTCs was 10500~124800 g?mol-1, the Mn was 6300~73000 g?mol-1, and the PDI was 1.59~1.73; PBTCs showed amorphous morphology and Tg was -3.43~70.90 ℃. PBTCs showed higher thermal stability than PBC. The results of film tensile test show that PBTC30(tensile strength 33.54 MPa, breaking elongation 275.69%) and PBTC40(tensile strength 32.13 MPa, breaking elongation 294.63%) have higher strength and toughness, and have certain application potential in film materials.
2023 Vol. 31 (1): 14-22 [
Abstract
] (
116
)
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(1 KB)
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(1962 KB) (
21
)
23
Design and Application of A Novel Chiral Thioether-phosphoramidite Ligand
Design and Application of A Novel Chiral Thioether-phosphoramidite Ligand[J]. journal1, 2023,31(1): 23-32')" href="#">
Feng Bin, LIN Yao, LIN Shuyu, PENG Liyan, ZHANG Xuelian, YOU Geyun
DOI: 10.15952/j.cnki.cjsc.1005-1511.22009
A novel chiral thioether-phosphoramidite ligand was synthesized by modular assemble protocol, which featured with short steps, multiple decorating sites and stable structure. The catalytic activity of ligand/Pd complex was investigated with asymmetric allylic alkylation reaction of rac-1,3-diphenylallyl acetate and dimethyl malonate. The solvent effect and base effect were examined, then the match/mismatch phenomenon of the axial chirality and point chirality was investigated. Finally, the influence of steric hindrance and electronic property of the sulfide motifs on the benchmark reaction were examined. Under the optimal reaction conditions, the target product can be obtained in -76% ee.
2023 Vol. 31 (1): 23-32 [
Abstract
] (
117
)
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(1 KB)
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(2152 KB) (
22
)
33
Synthesis and Fe
3+
Detection Property of A Novel Pyridine-Calix[4]arene Fluorescent Probe
Synthesis and Fe
3+
Detection Property of A Novel Pyridine-Calix[4]arene Fluorescent Probe[J]. journal1, 2023,31(1): 33-39')" href="#">
LI Yunjian, SHI Jing, XIAO Tangxin, SUN Xiaoqiang, YANG Ke, LI Zhengyi
DOI: 10.15952/j.cnki.cjsc.1005-1511.22019
A novel upper-rim functionalized pyridine-calix[4]arene flourescence probe for highly selective detection of Fe3+ was synthesized, and its structure was characterized by 1H NMR, 13C NMR and HR-MS, respectively. The results of ion detection experiments showed that the maximum absorption peak of the pyridine-calix[4]arene probe appeared at 295 nm and displayed a strong fluorescence emission band at 371 nm. Compared with other metal ions, the probe exhibits fluorescent quenching response to Fe3+ with high selectivity and strong anti-interference ability. The binding property of the probe with Fe3+ was studied by a combination of fluorescence titration and Job's plot, and the results indicated that a 2:1 coordination complex was formed by the probe with Fe3+, the association constant was 3.26×107 M-1, and the detection limit was 7.9×10-7 M.
2023 Vol. 31 (1): 33-39 [
Abstract
] (
96
)
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(1 KB)
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(2264 KB) (
28
)
40
Interactions between Pyrazine Carbazide Compounds with CT-DNA and
In Vitro
Antibacterial
Interactions between Pyrazine Carbazide Compounds with CT-DNA and
In Vitro
Antibacterial[J]. journal1, 2023,31(1): 40-51')" href="#">
ZHANG Yuzhen, LIU Xiangrong, YANG Zaiwen, ZHAO Shunsheng
DOI: 10.15952/j.cnki.cjsc.1005-1511.22131
Three novel pyrazine carbazide compounds C13H14N6O(a), C13H14N6O2(b) and C12H12N6O2(c) were synthesized from methyl 5-chloropyrazine-2-carboxylate and hydrazine hydrate by nucleophilic substitution and dehydration condensation reaction. Compounds a~c were characterized by elemental analysis and 1H NMR, which indicated the synthesized products were the target compounds. The single crystal of compound a was obtained by solvent evaporation method, and its crystal structure was determined to be monoclinic by X-ray single crystal diffraction. According to the UV-vis spectroscopy, compounds a~c interacted with CT-DNA in an insertion mode. Interactions between compounds a~c and CT-DNA were measured by microcalorimetric experiment. It was found that the reaction processes were exothermic, the thermal effects ΔH were -5.77×103, -5.50×103 and -5.96×103 kJ·moL-1 respectively, and the reaction time were less than 40 min. The results of the molecular docking simulation calculation showed that the specific binding sites of compounds a and b interacting with DNA included A-chain DC4 and DG5 as well as B-chain DC4, DG5 and DA6, the binding sites of compound c interacting with DNA included A-chain DC4 and DG5 as well as B-chain DC4 and DG5. The antibacterial activities of compounds a~c against B. subtilis, S. aureus, P. aeruginosa and E. coli were determined by Oxford cup method, and the results displayed that compounds a~c all exhibited better antibacterial activities against P. aeruginosa than the positive control tetracycline.
2023 Vol. 31 (1): 40-51 [
Abstract
] (
87
)
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(1 KB)
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(2617 KB) (
14
)
52
Study of Adsorption Behavior for The Removal of Methylene Blue in Water by Renewable Cellulose/Cyclodextrin Polymer
Study of Adsorption Behavior for The Removal of Methylene Blue in Water by Renewable Cellulose/Cyclodextrin Polymer[J]. journal1, 2023,31(1): 52-60')" href="#">
CHEN Wenjing, WU Yuanyue, XIE Zhiyin, YU Jinbei, PENG Qi
DOI: 10.15952/j.cnki.cjsc.1005-1511.22102
Renewable cellulose/cyclodextrin polymer (SUG-EPI-CDP) adsorbent was successfully prepared by extracting cellulose from bagasse to modify cyclodextrin polymer. The material was characterized by Fourier infrared spectrometer (FT-IR) and thermogravimetric analyzer (TGA), and the adsorption characteristics and mechanism of methylene blue (MB) on water were investigated. The results showed that under pH 7 and 30 ℃, the removal rate of MB could reach 80.9% within 120 min by SUG-EPI-CDP. The model fitting shows that the adsorption process is spontaneous and endothermic, which is fitted well with the pseudo-second-order kinetic equation and Langmuir isotherm model. The maximum adsorption capacity of SUG-EDI-CDP is 8.1 mg/g, which is much higher than that of other adsorbents prepared from waste. The results show that the adsorption capacity of cyclodextrin polymer can be improved effectively by using renewable cellulose, and a new way is provided for bagasse resource utilization.
2023 Vol. 31 (1): 52-60 [
Abstract
] (
85
)
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(1 KB)
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15
)
61
Synthesis, Characterization and Anticancer Activity of
Cis
-oxalate-dimycophenolic Acid-(
trans
-1,2-cyclohexanediamine)platinum(Ⅳ)
Synthesis, Characterization and Anticancer Activity of
Cis
-oxalate-dimycophenolic Acid-(
trans
-1,2-cyclohexanediamine)platinum(Ⅳ)[J]. journal1, 2023,31(1): 61-66')" href="#">
LIU Qixing, WANG Yingfei, XIE Lijiao, CONG Yanwei,
DOI: 10.15952/j.cnki.cjsc.1005-1511.22035
A new platinum(Ⅳ) complex, cis-oxalate-dimycophenolic acid-(trans-1,2-cyclohexanediamine)platinum(Ⅳ), was designed and synthesized. The structure was characterized by elemental analysis (EA), mass spectrometry (MS), Fourier transform infrared spectrometry (FT-IR) and nuclear magnetic resonance (NMR). The antitumor activity of the target compound was evaluated by methyl thiazolyl (MTT) method. The results showed that the structure of the compound was consistent with the expected assumption, and it had obvious inhibitory activity on the growth of 4 common cancer cells (SW480, HCT-116, A2780 and U-2OS). With the highest concentration of administration, the inhibition rates were 37.43%, 71.56%, 33.27% and 65.23% respectively.
2023 Vol. 31 (1): 61-66 [
Abstract
] (
129
)
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(1 KB)
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(1611 KB) (
32
)
67
Research Progress on the Synthesis of Isoquinoline
via
Silver Catalyzed Cyclization Reaction
Research Progress on the Synthesis of Isoquinoline
via
Silver Catalyzed Cyclization Reaction[J]. journal1, 2023,31(1): 67-81')" href="#">
NIU Yanning, YAN Wenxuan, ZHANG Jie, YAO Yingjia, XIA Xiaofeng
DOI: 10.15952/j.cnki.cjsc.1005-1511.22066
Isoquinoline skeleton compounds are a very important class of nitrogen-containing heterocyclic compounds. It widely exists in natural products with biological activities, organic materials and drug molecules. The traditional synthesis of isoquinoline requires harsh reaction conditions, so it is very important to construct this skeleton compounds under the mild condition. Silver catalyst can activate three bonds, and further reacts with nitrogen-containing nucleophiles by intramolecular nucleophilic addition, which is an important method for synthesizing isoquinoline derivatives. This paper mainly reviews the latest research progress in the construction of isoquinoline rings with 2-alkynyl benzylimine, 2-alkynyl benzylazide, 2-alkynyl benzaldehyde oxime, 2-alkynyl benzaldehyde hydrazone, and (2-(ethynyl)aryl)-1,2,3-triazoles as reactants via silver catalysis. The mechanism of some reaction was also discussed.
2023 Vol. 31 (1): 67-81 [
Abstract
] (
133
)
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(1 KB)
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52
)
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