Synthesis of Novel Pyrrole Derivatives with α,β-Unsaturated Ketones under Ultrasound Irradiation
ZHU Yan-ting1, SHAN Yan-qiang2, YAN Kun1, CUI Ke-ke1, LI Min1, WANG Shi-fan1
1. Department of Pharmaceutical Engineering, School of Ocean, Hainan University, Haikou 570228， China； 2. Qilu Pharmaceutical（Hainan）Co., LTD., Haikou 570314, China
Abstract：The intermediates, 5-formyl-3-methyl-1H-pyrrole-2,4-dicarboxylic ester（4a~4d）, were obtained by nitrosation, Knorr condensation and oxidization using ethyl acetoacetate and methyl acetoacetate as raw materials. Four novel pyrrole derivatives were synthesized by Aldol condensation of 4a~4d with acetone under ultrasound irradiation. The structures were characterized by IR, 1H NMR and HR-ESI-MS.
朱琰婷， 单衍强， 阎琨， 崔可可， 李敏， 王世范. 超声波促进合成新型吡咯α,β-不饱和酮[J]. 合成化学, 2015, 23(10): 963-966.
ZHU Yan-ting, SHAN Yan-qiang, YAN Kun, CUI Ke-ke, LI Min, WANG Shi-fan. Synthesis of Novel Pyrrole Derivatives with α,β-Unsaturated Ketones under Ultrasound Irradiation. Chinese Journal of Synthetic Chemistry, 2015, 23(10): 963-966.
2015, Vol. 23 
