|
|
Process Improvement on the Synthesis of Progesterone |
WU Qing-an1,2, XU Zhi-chao1, BAI Ting2 |
1. College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China; 2. Shanghai New Hualian Pharmaceutical Co. Ltd., Shanghai 201419, China |
|
|
Abstract Stigmasterol(1) was separated from phytosterol. The intermediate, 3-ketobisnor-4-cholenaldehyde(3) was prepared through oppenauer oxidation and ozonation from 1. Progesterone was synthesized by addition-condensation and oxygenation catalyzed by cuprous chloride from 3. The overall yield was 69.1%. The structure was confirmed by 1H NMR and ESI-MS.
|
Received: 28 January 2015
|
|
|
|
|
|
|