Abstract：Four 4-hydroxybenzaldehyde Schiff base derivatives(4a~4d) with phosphate ester group were synthesized by condensation reaction of primary amine with 2-(4-formylphenoxy)ethyl dimethyl phosphate（2）, which was prepared by etherification and esterification from 4-hydroxybenzaldehyde. The structures were confirmed by 1H NMR, 13C NMR, IR and ESI-MS. Their antidepressant activities were investigated by emergency model. The results showed that 2 and 2-｛4-［(methoxyimino)methyl］phenoxy｝ethyl dimethyl phosphate（4d） had certain antidepressant activities in vivo. And 2 showed the better antidepressant activity than imipramine.
刘进兵， 吴凤艳. 对羟基苯甲醛磷酸酯席夫碱衍生物的合成及其抗抑郁活性[J]. 合成化学, 2015, 23(10): 934-937.
LIU Jin-bing， WU Feng-yan. Synthesis and Antidepressant Activities of 4-Hydroxybenzal-dehyde Schiff Base Derivatives with Phosphate Ester Group. Chinese Journal of Synthetic Chemistry, 2015, 23(10): 934-937.
