Synthesis of Novel Maleimide-Pyrazolone-Derived MBH Carbonates by the Morita-Baylis-Hillman Reaction of Pyrazolediones with Maleimides
ZHENG Jinfeng, TANG Xue, PAN Xiaoli, ZHAN Gu*, HAN Bo*
State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
Abstract：Morita-Baylis-Hillman (MBH) carbonates are important organic synthetic intermediates. Thus, developing new types of MBH carbonates is of great interest. A Morita-Baylis-Hillman (MBH) reaction of pyrazolediones with maleimides has been developed in the presence of DABCO. Twelve novel maleimide-pyrazolone-derived MBH carbonates were obtained in 40%~87% yields. The structures were characterized by 1H NMR, 13C NMR and HR-MS (ESI).
郑金凤，唐雪，潘晓丽，詹固，韩波. 吡唑-4,5-二酮与马来酰亚胺的MBH反应合成新型马来酰亚胺-吡唑酮MBH碳酸酯类化合物[J]. 合成化学, 2023, 31(3): 204-209.
ZHENG Jinfeng, TANG Xue, PAN Xiaoli, ZHAN Gu, HAN Bo. Synthesis of Novel Maleimide-Pyrazolone-Derived MBH Carbonates by the Morita-Baylis-Hillman Reaction of Pyrazolediones with Maleimides. Chinese Journal of Synthetic Chemistry, 2023, 31(3): 204-209.
