Iodine catalyzed Friedel-Crafts Benzylation of 2,2,2-Trifluoro-1-(1H-indol-3-yl)-ethanol with Substituted Anilines
HAN Xiao-yu1, XIANG Yan-yan2, JIN Ning-ren2, WANG Yong-jiang1
１. School of Biological and Chemical Engineering/School of Light Industry, Zhejiang University of Science Technology, Hangzhou 310023, China; ２. College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China
Abstract：Eight novel 3-substituted indole derived anilines were firstly synthesized by Friedel-Crafts benzylation of 2,2,2-trifluoro-1-(1H-indol-3-yl)-ethanol with substituted anilines using iodine as the efficient catalyst. The yields were ６５%～９８%. The structures were characterized by 1H NMR， 13C NMRand HR-ESI-MS.
韩小瑜， 项艳艳， 金宁人， 王永江. 碘催化的2,2,2-三氟-1-(1H-吲哚-3-基)-乙醇与取代苯胺的傅-克苄基化反应[J]. 合成化学, 2015, 23(11): 1022-1025.
HAN Xiao-yu, XIANG Yan-yan, JIN Ning-ren, WANG Yong-jiang. Iodine catalyzed Friedel-Crafts Benzylation of 2,2,2-Trifluoro-1-(1H-indol-3-yl)-ethanol with Substituted Anilines. Chinese Journal of Synthetic Chemistry, 2015, 23(11): 1022-1025.
2015, Vol. 23 
