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| Synthesis of Androstane-2-eno［3,2-b］-indol-17-ol |
| GU Qing-mei, LIU Kai, LIU Zu-lang, ZHOU Zhuo-qiang |
| College of Science, South China Agricultural University, Guangzhou 510642, China |
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Abstract Androstane-2-eno［3,2-b］-indol-17-ol(5) with the total yield of 43.2% was synthesized by hydroxyl oxidation, carbonyl protection, carbonyl reduction and Fischer indole synthesis using dehydroepiandrosterone as the starting material. The structure was confirmed by 1H NMR, IR and MS. The results of the biological activity tests on culex pippens showed that comparing with dihydrotestosterone, the insecticidal activity of 5 increased significantly, and the insecticidal rate was 41.5％ at 400 mg·L-1.
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Received: 26 January 2015
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2016, Vol. 24 
