1. 湖北大学 a. 有机化工新材料湖北省协同创新中心； b. 化学化工学院； c. 生命科学学院，湖北 武汉 430062
Synthesis and Biologial Activities of Novel Magnolol -2-Azomethine Derivatives
MEI Fan1a,1b, ZHAI Ting1a,1b, ZHENG Nian1a,1b, LI Yan1a,1b, CHEN Yong1a,1c, LOU Zhao-wen1a,1b
a. Organic Chemical Materials Collaborative Innovation Center in Hubei; b. Chemistry and Chemical Engineering; c. College of Life Sciences, 1. Hubei University, Wuhan 430062, China
Abstract：The formoxyl was introduced into the ortho-position of magnolol hydroxy by the Reimer-Tiemann method using magnolol as the raw material. Four novel mono-substituted and one bis substituted magnolol 2-azomethine derivatives were synthesized by reaction of the formylated magnolol with glycine, glutamic acid, arginine and sulfanilamide, respectively. The structures were characterized by UV-Vis, 1H NMR, IR, MS and elemental analysis. The myoblast cell toxicity and the effects on CYPs in liver microsomes in vitro human were investigated. The results showed that 2-(N-glycine)magnolol azomethine(3a) exhibited certain tomyoblasts toxicity. At 64 μmol·L-1, the inhibition rate of 2-［N-(4-sulfamoyl-phenyl)］-magnolol azomethine(3d) on CYP2D6 and CYP1A2 was 42.9% and 36.8%, respectively.
2016, Vol. 24 
