Abstract：A series of Phloretamide derivatives were designed and synthesized using 3-(4-hydroxyphenyl)propan-amide as the lead compound. They were synthesized by amidation reaction， using cinnamon acids as the raw materials. 3-(3,4,5-trihydroxyphenyl)acrylamide(2f), 3-(2,3,4-trihydroxyphenyl) propanamide(3e) and 3-(3,4,5-trihydroxyphenyl) propanamide(3f) are new compounds. The structures were characterized by 1H NMR, 13C NMR and ESI-MS. The antioxidant activities of these compounds were investigated. The results showed that 3-(3,4-dihydroxyphenyl)acrylamide(2b), 3-(3,4,5-trihydroxy-phenyl)acryl-amide(2f) and 3-(3,4,5-trihydroxyphenyl)propanamide(3f) had good antioxidant activities with radical scavenging ratio of 66.8%, 59.8% and 69.4% at 10 μmol·L-1, respectively， better than caffeic acid, caffeic acid phenethyl ester and Vc.
吴冬冬, 樊志强, 任杰, 胡昆. Phloretamide及其衍生物的合成与抗氧化活性[J]. 合成化学, 2016, 24(3): 211-214.
WU Dong-dong, FAN Zhi-qiang, REN Jie, HU Kun. Synthesis of Phloretamide and Its Derivatives and Their Antioxidant Activities. Chinese Journal of Synthetic Chemistry, 2016, 24(3): 211-214.
2016, Vol. 24 
